Mar 4, 2022
This podcast is about big ideas on how technology is making life better for people with vision loss.
The Enigma machines that Germany used to encode messages during World War II were notorious for their complexity. Two Enigma experts — Dr. Tom Perera, a retired neuroscientist, and founder of EnigmaMuseum.com, and Dr. Mark Baldwin, an expert on the story of Enigma machines — tell us how the Allies were able to crack the code, by using input-output mapping.
The human brain is similarly complex. Until recently, no one knew the code the retina used to communicate with the brain to create sight. Our guest, Dr. Sheila Nirenberg, a neuroscientist at Weill Cornell, and Principal and Founder of Bionic Sight has — using input-output mapping — cracked the retina’s neural code, enabling her to recreate the electric signals to the brain that could restore sight in people with retinal degeneration. She has created a set of goggles that convert a camera’s images into the code, via pulses of light. And she relies on optogenetics, a relatively new procedure in neuroscience that helps neurons become responsive to light. In her clinical trial, Dr. Nirenberg injects the optogenetic vector into the eye, and trial participants who are completely blind, like Barry Honig, who we speak with on this program, report being able to see light. In early studies, coupling the effects of the optogenetics with the code-enabled goggles has an even more impressive effect on patients’ vision. Dr. Nirenberg is also using her knowledge of the visual neural code to inform machine learning applications that could also be further used to support people who are blind or visually impaired. Clinical trial participants are important partners in the journey of discovery, Dr. Nirenberg says. Barry Honig agrees. He was happy to participate to help ease the burden on future children diagnosed with eye diseases that would otherwise result in blindness, but thanks to these advancements, someday may not.
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